Niagen Plus
What is Niagen Plus?
Niagen Plus is a pharmaceutical-grade form of NiagenĀ® (nicotinamide riboside chloride), designed for intravenous (IV) and injectable administration under medical supervision. NiagenĀ® is patented nicotinamide riboside chloride (NRCl), a form of vitamin B3 that serves as a precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme essential for cellular energy production, repair, and supports metabolic resilience.Ā¹
How is Niagen Plus different from Tru NiagenĀ®?
Tru NiagenĀ® is a food-grade dietary supplement taken orally and available directly to consumers.
Niagen Plus is a pharmaceutical-grade, prescription-only formulation administered by a healthcare professional or under medical guidance, designed for intravenous or injectable administration.
What is NAD+ and why does it matter?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in the body and is essential for hundreds of biological processes including cellular energy metabolism and cellular health. NAD+ levels naturally decline with age and chronic exposure to metabolic stressors, which is one reason why strategies to support NAD+ production have gained significant scientific interest.
How does Niagen Plus work?
Niagen Plus delivers nicotinamide riboside (NR), a precursor molecule that cells use to produce NAD+. Niagen IV bypasses digestion for 100% bioavailability, providing NR that your cells can convert into NAD+ to support cellular energy and metabolic health.Ā¹
Do I need a prescription for Niagen Plus?
Yes. Niagen Plus therapies require a prescription and must be administered or supervised by a licensed healthcare professional.
Who administers Niagen Plus treatments?
Niagen Plus treatments are administered by trained medical professionals in licensed clinics, or self-administered at home under prescription-only, clinician-directed guidance.
Who may benefit from Niagen Plus therapy?
Healthcare providers may recommend Niagen Plus for individuals seeking cellular health support. A qualified medical professional will determine if treatment is appropriate for your individual health needsĀ¹
Is Niagen Plus safe?
NiagenĀ® (nicotinamide riboside chloride), the active ingredient in Niagen Plus, has been evaluated in 40+ published human clinical studies in oral form, with documented tolerability.
For the IV formulation, a randomized, placebo-controlled pilot studyĀ² evaluated acute response, and a peer-reviewed retrospective tolerability studyĀ³ in a real-world clinical setting reported minor transient experiences and no clinically significant changes in liver enzymes or inflammatory markers at 30 days post-infusion.
Subcutaneous administration (NiagenĀ® At-Home Injection Kit) has been clinically studied and shown to be safe and well-tolerated in human studies
Niagen Plus is prescription-only and administered or prescribed by licensed healthcare professionals.Ā¹
How do I find a clinic that offers Niagen Plus?
You can locate authorized clinics and providers through the Niagen Plus Clinic Locator on the Niagen Plus website.
Niagen IV
What is Niagen IV?
Niagen IV is an intravenous therapy that delivers pharmaceutical-grade NiagenĀ® (nicotinamide riboside chloride) directly into the bloodstream to support NAD+ production.Ā²
How is Niagen IV different from NAD+ IV therapy?
Niagen IV delivers NRCl, which delivers NR into the cell, where it converts to NAD+. Traditional NAD+ IV therapies deliver NAD+ directly, which cannot cross the cell membrane intact. Your body must break it down into its smaller components, including NR, which crosses the cell membrane directly. A randomized, placebo-controlled pilot study found that Niagen IV increased NAD+ levels 20% more than NAD+ IV, peaking at three hours post-infusion.Ā²
How long does a Niagen IV treatment take?
Treatment time may vary depending on dosage and provider protocols. Your healthcare professional will determine the appropriate infusion schedule.
How often should I receive Niagen IV?
Treatment frequency varies based on individual goals and provider recommendations. Some patients receive treatments periodically, while others may follow a structured program recommended by their healthcare professional.
What should I expect during a Niagen IV session?
During treatment, a healthcare professional places an IV line to deliver the therapy. Patients typically relax in a comfortable setting while the infusion is administered.
Are there any side effects?
Expected side effects may include jaw tingling or tightness. Your healthcare provider will discuss potential side effects and monitor your treatment.
NiagenĀ® At-Home Injection Kit
What is the Niagen At-Home Injection Kit?
The Niagen At-Home Injection Kit provides a prescription formulation of NiagenĀ®designed for subcutaneous injection outside of a clinic setting, under medical supervision and guidance from a licensed healthcare provider. Niagen Bioscience is not the manufacturer or compounder of this product. Compounding is performed by a licensed 503B outsourcing facility.
How does the at-home injection program work?
After purchasing the At-Home Injection Kit, patients will be prompted to complete a medical intake questionnaire. Once the questionnaire is complete it will be reviewed by a licensed physician who determines whether treatment is appropriate. If prescribed, the injection kit is shipped along with instructions and provided medical guidance for proper administration.
What type of injection is used?
The Niagen At-Home Injection Kit is designed for subcutaneous administration ā injections into the fatty tissue layer beneath the skin. Your licensed provider will determine the appropriate administration method. The most common injection site for subcutaneous injection is in the abdomen.
Do I still medical supervision if I inject at home?
Medical supervision is provided through a licensed telehealth provider. Even though injections may be performed at home, the treatment requires a prescription and ongoing management by a licensed healthcare professional. If you have any questions regarding the treatment you can reach out to your provider by navigating to your account, then to your order. Within your order there is a chat button for you to communicate directly with the provider who approved your prescription.
Is the at-home injection the same as Niagen IV?
No. While both deliver NiagenĀ®, Niagenā¢ IV is administered intravenously in a clinical setting, while the NiagenĀ® At-Home Injection Kit uses subcutaneous injections that can be administered outside the clinic, with prescription, medical guidance and delivered directly to your door.
How often do I use the injection kit?
Dosage and frequency depend on the treatment plan established by your healthcare provider.
Who should not use Niagen injectable therapy?
Niagen injectable therapy may not be appropriate for everyone. Eligibility depends on individual health history and is determined during your telehealth consultation. Only a qualified, licensed medical professional can confirm whether treatment is right for you. Niagen Plus is not intended for use by children.
Is the Niagen At-Home Injection Kit available in my state?
Availability varies by state. Some states have restrictions on the shipment of compounded prescription products, and eligibility is confirmed as part of the telehealth consultation process. If your state isnāt one thatās excluded, start the intake process and we'll confirm eligibility directly.
What is your refund policy?
- All purchases require completion of a medical intake form and physician review.
- Prescription approval is not guaranteed.
- If your prescription is not approved after medical review, you will receive a full refund within 7ā10 business days.
- If you are found ineligible during the intake process, contact our support team and we will process your refund.
- If you do not complete your intake form within 30 days, your order will expire and you will be automatically refunded.
- Once a prescription has been approved and issued, the order is final and cannot be refunded or returned.
Can I get more information about the prescribing physicians for the Niagen At-Home Injection Kit?
Are your clinicians licensed?
- Yes. All providers are licensed physicians practicing within your state.
Can you list your providers for Rhode Island and Vermont
- In accordance with the laws and regulations in Vermont and Rhode Island, you can click here for a list of providers prescribing for those states.
What about all other states?
- If you have questions about the providers in your state, please reach out. Our customer service team is happy to help.
Still have questions?
Get in touch with us here.
Formulation & Transition
Has the NiagenĀ® At-Home Injection Kit changed?Ā
As of October 19, 2026, we've upgraded the NiagenĀ® At-Home Injection Kit from a lyophilized powder to a sterile, ready-to-inject liquid formulation. There's no mixing or reconstitution required, fewer components and fewer steps, for a simpler at-home experience.
Do I still need to reconstitute or mix the medication?Ā
No. The liquid formulation is ready to draw and inject as prescribed. Simply follow the dosing instructions in your Patient Instructions for Use.
I still have powder-format vials from a previous order. Do I need to switch to the new formulation?Ā
You can continue using any previously prescribed kit as directed by your provider. Future orders will ship with the new liquid formulation. If you have questions about your dosing, treatment protocol, or how to use your prescribed medication, including mixing/reconstitution of a previous powder-format kit, please contact your provider through your account by selecting the applicable order and clicking āChat with your doctor.ā For order, shipping, or other non-clinical support questions, our Customer Experience team is happy to help.
Why did the NiagenĀ® At-Home Injection Kit change?Ā
This reflects our ongoing commitment to make prescription NiagenĀ® therapy as simple and accessible as possible. The active ingredient and clinician-directed protocol remain the same; we've simply streamlined the at-home experience.
Dosing, Kit Contents & Treatment CourseĀ
What is included in my kit?Ā
Your NiagenĀ® At-Home Injection Kit includes everything you need for your prescribed injections:
Injection Vial
- 1 Ć 5 mL vial containing 500 mg of nicotinamide riboside chloride total (100 mg/mL), providing 5 doses of 1 mL each (100 mg per dose)
Alcohol Prep Pads
- 10 Ć alcohol prep pads
Syringes for Injection
- 10 Ć 1 mL syringes
How many doses come in oneĀ NiagenĀ® At-Home Injection Kit?Ā
For the liquid ready-to-inject vial (if purchased after October 22, 2026):
- There are a total of 5 doses in one NiagenĀ® At-Home Injection Kit. Each dose is 1 mL (100 mg) and should be administered every 5 days. Please be sure to follow your provider instructions based on your prescription.
For the powder for reconstitution vial (if purchased before October 8, 2026):
- The number of doses and concentration depends on the treatment plan your provider prescribes. Your specific dose and schedule are outlined by your provider.
If you have questions about your dosing, you can message your provider directly. Sign in to your account using the one-time passcode sent to your email, click Orders, then select your specific order. Each order is tied to its own prescription, and you'll find a "Chat with your doctor" button where you can ask about your dosing directly.
How long does one NiagenĀ® At-Home Injection Kit last?Ā
NiagenĀ® At-Home Injection kits will vary depending on the protocol your provider recommends and are designed to last approximately one month. You can check your specific treatment course details in your account or your Patient Instructions for Use.
Will my dose or strength change with the new liquid formulation?Ā
The liquid formulation comes in a single concentration, 500 mg per 5 mL vial (100 mg/mL). This replaces the two concentrations available with the powder format (50 mg/mL and 100 mg/mL), since that version required patients to reconstitute their own dose with Bacteriostatic Water.
Depending on your previous prescription, your provider may adjust the volume you inject, so your total dose stays consistent. Your updated protocol will be reflected in your Patient Instructions for Use. If you have questions about your specific transition, you can message your provider directly through your account.
How do I know when to reorder?Ā
You'll receive a reorder email approximately 23 days from your ship date, directing you to the refill product and a shortened refill intake form, quicker to complete than your original intake.
Does the NiagenĀ® At-Home Injection program have a loading phase and maintenance phase?Ā
No. The NiagenĀ® At-Home Injection Kit program does not use a standard loading phase followed by a maintenance phase. Your licensed provider determines your prescribed dose and treatment schedule.
Always follow the dosing instructions in your Patient Instructions for Use.
Pricing & Value
What's included in the $199 price?Ā
Your purchase includes a telehealth consultation with a licensed provider, medical intake review, and, if prescribed, your NiagenĀ® At-Home Injection Kit dispensed and shipped directly to your door via next-day air shipping, at no additional cost. Your order will be shipped only after you have received your prescription. Please make sure to complete your intake form and that you have received a message from your provider with prescription approval.
Completing the intake doesnāt guarantee a prescription; if the licensed provider doesnāt prescribe NiagenĀ® At-Home injections for you, you'll receive a full refund.
The $199 price applies to each order and is not a recurring monthly charge.
Are discounts or promotions available for the NiagenĀ® At-Home Injection Kit?Ā
New customers receive a welcome offer on their first order, and returning customers may receive exclusive offers by email. Each offer can be used once per customer and can't be combined with other codes. Other discounts and promotions, including the military discount, do not apply to the NiagenĀ® At-Home Injection Kit.
Product & Formulation Differentiation
Why NR instead of NAD+ directly?Ā
NAD+ is a large molecule that has difficulty entering cells intact. Nicotinamide riboside (NR), the active ingredient in NiagenĀ® and a precursor (building block) to NAD+, is smaller and can be taken up by cells directly, where itās converted into NAD+. This is why we deliver NR rather than NAD+ itself, whether by injection or IV.
How is Niagenā¢ Plus different from other NAD+ injection or IV products?Ā
Many NAD+ products on the market deliver NAD+ directly, which the body must break down before it can be used by the cells. Niagenā¢ Plus delivers NR, a precursor (building block) to NAD+, which enters cells directly.
How is the NiagenĀ® At-Home Injection Kit different from oral Tru NiagenĀ®?Ā
Both deliver patented NiagenĀ® nicotinamide riboside (NR), a precursor (building block) to NAD+, but different formats.
Tru NiagenĀ® is an oral supplement that is manufactured as a food-grade ingredient. The NiagenĀ® At-Home Injection Kit is prescription-only, clinician-directed, and uses a subcutaneous injectable format that is pharmaceutical-grade with a prescribed dosing protocol.
The injectable format is another delivery option for NiagenĀ®. A licensed provider determines whether the At-Home Injection program is appropriate for you.
Is the NiagenĀ® At-Home Injection Kit FDA approved?Ā
No. The Niagen At-Home Injection Kit is a compounded drug product, and FDA does not approve compounded drugs. FDA has not reviewed these products for safety, effectiveness, or quality before they are sold.
Niagen At-Home Injection Kits are compounded and distributed by outsourcing facilities registered with FDA under Section 503B of the Federal Food, Drug, and Cosmetic Act. These facilities must follow FDAās current good manufacturing practice (CGMP) requirements, and FDA inspects them.
How should the NiagenĀ® At-Home Injection Kit liquid vial be stored, and what is the shelf life once opened?Ā
Store your NiagenĀ® At-Home Injection Kit liquid vial in the refrigerator at 2Ā°C to 8Ā°C (35Ā°F to 46Ā°F), away from direct light, and do not freeze. An unopened vial is good until the beyond-use date (BUD) printed on the label. Once you puncture the vial for your first dose, the printed BUD no longer applies: use the remaining medication within 28 days, then discard any solution that's left.
To keep your vial in good condition:
Keep it refrigerated at 2Ā°C to 8Ā°C (35Ā°F to 46Ā°F). Do not freeze.
Protect it from direct light, heat, and moisture, and don't store it in the bathroom.
Keep it out of the reach of children.
Before first use, check the beyond-use date printed on the label.
After first use, write the date of the first puncture on the label so you know when your 28 days end.
If you miss a dose, take it as soon as possible, as long as it's within the 28 days after the first puncture. Never take more than one dose per day. Always follow your prescribing physician's instructions and contact support if your vial was exposed to extreme temperatures during shipping.
How do I administer a subcutaneous injection? Does it hurt?Ā
Please follow this link to the NiagenĀ® At-Home Injection Kit How-to page where you will find step-by-step instructions on how to administer your subcutaneous injection. Every person reacts differently to subcutaneous administration, but there have been no serious adverse events reported.
Is the NiagenĀ® At-Home Injection Kit HSA/FSA eligible? Is it covered by insurance?Ā
The NiagenĀ® At-Home Injection kit is not currently covered by insurance. The kit is not yet HSA/FSA eligible, but our team is working hard to make this available.
What is the refund or cancellation policy beyond the refund I would receive if not prescribed?Ā Ā
All purchases require completion of a medical intake form and physician review.
Prescription approval is not guaranteed.
If your prescription is not approved after medical review, you will receive a full refund within 7ā10 business days.
If you are found ineligible during the intake process, contact our support team and we will process your refund.
If you do not complete your intake form within 30 days, your order will expire and you will be automatically refunded.
Once a prescription has been approved and issued, the order is final and cannot be refunded or returned.
How long does it take to get a NiagenĀ® At-Home Injection Kit prescription after intake?Ā
Most customers receive a prescription decision within 48-72 hours of completing their online intake. A licensed clinician reviews your health information, and once your prescription is approved, your NiagenĀ® At-Home Injection Kit ships free via next-day air. In total, you can typically expect your kit to arrive within 3ā5 business days of finishing your intake. Please note that clinician reviews and shipments are processed on business days only, so intakes completed on a weekend or holiday will be reviewed the next business day.
- Hawkins J, Idoine R, Kwon J, Shao A, Dunne E, Hawkins E, Dawson K, Nkrumah-Elie Y. Randomized, placebo-controlled, pilot clinical study evaluating acute NiagenĀ®+ IV and NAD+ IV in healthy adults. medRxiv. 2024. doi: 10.1101/2024.06.06.24308565. This study is a preprint and has not yet been peer-reviewed.
- Reyna K, Heinzen G, Patel N, Ritter M, Siojo A, Legere H, Pojednic R. Intravenous infusion of nicotinamide adenine dinucleotide (NAD+) versus nicotinamide riboside (NR): a retrospective tolerability pilot study in a real-world setting. Front Aging. 2026 Feb 2;7:1652582. doi: 10.3389/fragi.2026.1652582. Infusion times reflect a real-world clinical setting. Individual experiences may vary.
ā NiagenĀ® At-Home Injection Kit is only available if prescribed after an online consultation with a healthcare provider. The statements on this page have not been evaluated by the FDA. Results may vary. If you notice any side effects while using this treatment, contact your healthcare provider immediately.
*The statements on this page have not been evaluated by the FDA. Results may vary. If you notice any side effects while using this product, contact your healthcare provider immediately.
